One shot of closure is generally not very harmful, but if used for a long period of time, it may cause allergic reactions, necrotizing fasciitis and other adverse reactions. Closure therapy is a common orthopedic treatment, closed needle is composed of local anesthetic and hormone, can relieve the pain symptoms caused by local aseptic inflammation, and can be quickly anti-inflammatory; the harm of playing closed depends on the adverse reaction of the drug itself and the damage caused by improper puncture operation. Sealing is a kind of invasive treatment, the hormone component inside the sealing needle can aggravate the risk of infection, for diabetes and blood sugar control is not good patients, in the sealing treatment will have a higher risk of infection, so in the process of operation should be strictly abide by the principle of asepsis. In addition, local anesthetic will also cause allergic reaction, severe anaphylactic shock and other symptoms. Improper puncture operation can occur nerve damage, tendon rupture, etc., this is due to the puncture site near the nerve or tendon and cause damage, if the drug injection is too much, it is also easy to lead to the necrosis of the foot tissue, causing necrotizing fasciitis. If there is an adverse reaction to a single shot of closure, it should be stopped immediately and the treatment program should be changed under the guidance of a medical professional.