Swelling from a bee sting should be immediately applied topically with ammonia, or sodium bicarbonate solution, or local wet compresses of aluminum acetate solution. If the swelling is significant, oral antihistamines, or systemic glucocorticosteroid therapy, and local wet compresses of estazadine lactate solution should be applied. The venom is injected into the skin and causes local or systemic reactions. The composition of the venom discharged by the bee is complex and varies from species to species, but all contain mediators such as histamine, 5-hydroxytryptamine, bradykinin, cholinesterase, etc. Bee venom is also antigenic, and some antigens can cause strong, rapid-onset allergic reactions, mostly in people with genetic allergies. The bee sting mostly occurs in the exposed area, where the sting immediately feels burning pain, followed by redness and swelling, and even blistering, with a bruise or broken stinger in the center. If you’ve been stung in more than one place, you can find a large area of redness and swelling, especially in the loose tissue areas such as eyelids and lips, where the edema is more pronounced and both painful and itchy. Therefore, after being stung by a bee, you should be treated immediately and actively with oral antihistamines or glucocorticosteroid systemic therapy, as well as local symptomatic treatment.