Glioma surgery technology 1. Intraoperative electrophysiological monitoring-protection of brain function Tumors located in or near functional areas or deep in the brain are very likely to cause damage to nerve cells and their nerve fibers in functional areas during surgical resection, which in turn causes symptoms of neurological deficits and seriously affects patients’ survival cycle and quality of life. Our center is the first in China to carry out intraoperative wake-up anesthesia under functional imaging to guide functional area monitoring, which effectively protects patients’ functions such as motor, language, spatial cognition and digital cognition, and has the largest number of cases in China. At the same time, combined with intraoperative cortical EEG tracing to effectively monitor the epileptic foci, the corresponding epileptic foci can be treated with low-power electrocautery, which can maximize the removal of the tumor and preserve the related neurological functions and reduce the complications of surgery. 2. Cognitive function evaluation-protection of brain function In China, we have cooperated with national key laboratories such as the Cognitive Neuroscience and Learning Laboratory of Beihang University, the Institute of Psychology of Chinese Academy of Sciences and the Institute of Automation of Chinese Academy of Sciences to be the first to apply brain cognitive function and neuropsychological evaluation technology to the treatment of glioma to protect patients’ postoperative quality of survival and quality of life. Glioma and epilepsy Glioma often has epilepsy as its first symptom. We have developed a comprehensive clinical treatment technique for glioma complicated by epilepsy, which has greatly reduced postoperative epilepsy in patients with low-grade glioma and has reached the international advanced level. Molecular neuropathological diagnosis Molecular neuropathological diagnosis is the diagnosis and typing of glioma at the gene and protein level, and combined with the histopathological diagnosis, it can better guide the individualized radiotherapy, chemotherapy and targeted therapy, and help judge the prognosis of patients. Functional MRI technology We are the first in China to conduct research on the relationship between glioma and functional areas, and to apply functional MR to determine the efficacy of radiation therapy, chemotherapy, and targeted therapy for glioma, maximizing modern functional imaging technology and protecting patients’ functions. Individualized radiotherapy Using methods such as conformal radiotherapy, we can design more reasonable radiotherapy plans for different tumor nature, grade and corresponding physical condition of patients, inactivate the remaining tumor cells after surgery and make the tumor shrink or disappear. Individualized chemotherapy According to the tumor histopathology and molecular pathology, combined with the patient’s physical condition and the results of various auxiliary examinations, a targeted chemotherapy program is designed for different patients, which can more effectively kill tumor cells of different proliferation cycles and prevent tumor recurrence, especially for tumors of infiltrative growth and multifocal growth. Molecular targeted therapy is designed according to the molecular genetic signaling system of glioma occurrence and growth, and the targeted application of target-specific blocking drugs can significantly improve the tumor-free survival of patients, which is one of the most advanced techniques in the treatment of glioma internationally. Currently, the most commonly used molecular targeted drugs for neurological malignancies are VEGF monoclonal antibodies (such as bevacizumab) targeting blood vessels, because tumor growth and proliferation need constant neovascularization to provide, so neovascularization is a characteristic of tumors, and effective inhibition of neovascularization will have a significant therapeutic effect on tumor growth. Meroval for the treatment of lymphoma is an anti-CD20 monoclonal antibody, such as rituximab. In addition, some drugs that act on signaling pathways are commonly used, because tumor growth requires signaling, if the signaling is aborted, the tumor will apoptosis, commonly used drugs such as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. Currently, the drug therapy of tumor is in the transition period from pure cytotoxic attack to combined therapy with molecular targeting, and cytotoxic drugs combined with molecular targeting drugs for glioma have become the direction to replace traditional chemotherapy.