Air leakage from the lung after open heart surgery for lung cancer is caused by the lung wound not healing and is a more common surgical complication. Open heart surgery for lung cancer treatment will remove part of the lung tissue, and after removal, there is a surgical wound in the lung tissue, and there will be a small amount of air leakage until it heals. A small amount of air leakage can be adequately drained through closed chest drainage, and it will have less impact on the patient, and other than that, it will heal by itself without special treatment. If the air leak is large, especially if the bronchial break is not healed, the probability of self-healing is low, and surgery should be considered for re-suturing. Therefore, air leakage after open heart surgery for lung cancer is a common surgical complication, which should be dealt with timely according to patient’s specific situation.