The severity of weakly positive antinuclear antibodies cannot be generalized, but may be associated with systemic lupus erythematosus, mixed connective tissue disease, scleroderma and other diseases, the severity of which should be further analyzed according to the patient’s specific type of disease, individual physical condition and other factors. Antinuclear antibody belongs to autoantibodies, and its weak positive test result often suggests that the patient may have SLE, mixed connective tissue disease, scleroderma and other diseases. However, only relying on the results of the antinuclear antibody test cannot confirm the diagnosis of the above diseases, and it is necessary to analyze the results together with auxiliary examinations, physical signs, medical history and other clinical clues. If the patient’s overall physical condition is poor, accompanied by chronic diseases, and diagnosed with systemic lupus erythematosus, mixed connective tissue disease, scleroderma and other diseases, the condition is relatively serious; while some healthy elderly people may also have weakly positive antinuclear antibodies, which is not a serious situation. Laboratory reports need to be interpreted by a professional physician, and it is recommended that patients with weakly positive antinuclear antibodies go to the Department of Rheumatology and Immunology of a regular hospital for detailed consultation.