Usually, a doctor will only consider switching to another antimicrobial, such as a cephalosporin, if the patient’s symptoms of the infection are not relieved or are not controlled after 72 hours of taking amoxicillin. Amoxicillin is a penicillin antibiotic and drugs such as ceftriaxone are cephalosporins. If the use of amoxicillin is effective afterward and controls the local infection well, there is no need to switch to a cephalosporin. Depending on the type of infection and the pathogen of the infection, the choice of amoxicillin or the need to switch to a cephalosporin after 72 hours will be determined. Amoxicillin is a penicillin antibiotic and is contraindicated in patients who are allergic to penicillin and have a positive penicillin skin test. If patients taking amoxicillin symptoms are not relieved, it is recommended to change the drug under the guidance of the doctor, do not change the drug on your own to avoid adverse consequences.