Generalized tonic-clonic epilepsy can be partially cured, while some patients need to take lifelong antiepileptic drugs. Generalized tonic-clonic seizures are one of the types of epileptic seizures, which can be manifested as sudden loss of consciousness, generalized tonus, convulsions, etc. They can be secondary to cerebral hemorrhage, traumatic brain injury, encephalitis, etc., and are also genetically related. The clinical prognosis of the disease varies greatly among patients, and is correlated with its cause, age, seizure frequency, and treatment. Secondary seizures caused by cerebral hemorrhage may be cured if the cause of the seizure is effectively treated and corrected. Some patients with secondary epilepsy, as well as those with genetically related epilepsy, usually rely on lifelong use of antiepileptic drugs, such as valproate, etc., and most of these patients can reduce or even avoid seizures through drug treatment. However, there are some patients who cannot effectively control their seizures even after medication and surgery. The recurrence of epilepsy leads to repeated ischemia and hypoxia of the brain cells, which affects the patient’s intellectual level and quality of life, and even triggers respiratory and cardiac arrests during acute seizures, leading to death. Generalized tonic-clonic epilepsy should be treated as early as possible in a regular medical institution, follow the physician’s instructions, and be treated aggressively to control the disease and obtain as good a prognosis as possible.