Realistic nodule in the right submandibular gland may be due to pleomorphic adenoma or mucoepidermoid carcinoma, and the treatment is mainly based on surgery with postoperative radiotherapy, as follows. The envelope of pleomorphic adenoma and mucoepidermoid carcinoma is often incomplete, so when surgical resection is performed, the submandibular gland should be resected together with the tumor, so as to prevent postoperative recurrence. For those with enlarged lymph nodes and suspected lymph node metastasis, selective cervical lymphadenectomy should be performed. For low-differentiated mucoepidermoid carcinoma, postoperative radiotherapy should be performed, which can be external irradiation or intra-tissue irradiation with iodine 125. The realistic nodule in the right submandibular gland may also be other diseases, and it is recommended to go to the hospital in time for consultation and targeted treatment after clarifying the cause of the disease.