Dry and rough back of hands may be caused by skin dehydration, lack of vitamins, ichthyosis and other reasons. 1. Skin dehydration: when the weather is dry or the skin is attacked by cold air, it will lead to the evaporation of skin moisture, thus causing dry and rough skin, because the back of the hand is in direct contact with the air, this dry and rough situation may be more serious. Some patients also appear in the bath after the symptoms of the whole body itching. 2. Lack of vitamins: the so-called dry and rough skin may also be caused by the lack of vitamins, when the body lacks vitamin B2, may lead to metabolic failure, thus causing the skin flaky and dry situation. When the lack of vitamin C, may lead to accelerated aging of the skin, unable to lock moisture, thus causing dry and rough skin. 3. Ichthyosis: Ichthyosis can also cause dry, rough, flaky skin and other symptoms, this disease is mostly due to heredity, usually can not be cured. When patients have dry and rough skin on the back of the hand, they should take good care of their hands and seek medical treatment in time to avoid aggravation of the situation.