Clinically there is no non-buxostat and benzbromarone clinical which is safer to say, both belong to the uric acid lowering drugs, the mechanism of action is different, resulting in adverse reactions are not the same. It is recommended to consult a doctor for specific medication. 1. febuxostat: febuxostat is a xanthine oxidase inhibitor, can inhibit the production of uric acid, reduce uric acid. It can be used in the treatment of long-term hyperuricemia in gout patients, but some patients may experience adverse reactions such as liver function abnormalities, nausea, arthralgia, and skin rash. Allergic to the components of this product is prohibited, patients who are receiving azathioprine, mercaptopurine treatment is prohibited for pregnant women to use with caution, lactating women to stop breastfeeding when using the drug. Note that before the first use of this product should be a liver function test, severe renal insufficiency should be used with caution, to avoid the use of gouty arthritis in acute attacks. 2. Benzbromarone: It can promote uric acid excretion, treat primary uric acidemia, gout and non-acute attacks of gouty arthritis. Some patients may experience gastrointestinal discomfort, such as nausea, vomiting, feeling of fullness in the stomach and diarrhea, and other adverse reactions, and liver injury may occur in severe cases. It is contraindicated in those who are allergic to the product, in those with moderate to severe renal impairment and in patients with kidney stones, and in pregnant and lactating women. Note that it can not be used during the acute attack of gout, need to drink a lot of water during the treatment, the initial dose as small as possible, long-term use of the drug need to regularly check the liver and kidney function. The specific use of drugs need to follow the instructions of the doctor, if there are adverse reactions, you need to go to the hospital.