Table 3 WHO/ISUP nuclear grading criteria for renal cell carcinoma, 2016 edition

Grading

Definition

 
Level 1

 
Nuclei absent or inconspicuous under 400× microscopy, basophilic

 
Grade 2

 
Nuclei distinct at 400×, eosinophilic, visible but not prominent at 100×

 
Grade 3

 
100× nuclei clearly visible, eosinophilic

 
Grade 4

 
Significant nuclear pleomorphism, polymorphic giant cells and/or rhabdomyosarcoma-like and/or sarcoma-like differentiation may be seen