Symptoms of creatinine 130μmol/L mainly depend on the cause of creatinine elevation. If it is caused by physiological reasons such as high muscle content or eating more meat in general, there is usually no uncomfortable symptoms; if it is caused by pathologic reasons such as acute kidney injury or chronic renal insufficiency, symptoms such as edema, increased nocturia, and fatigue may occur. Normal serum creatinine ranges from 53 to 106 μmol/L in men and from 44 to 97 μmol/L in women. Therefore, a creatinine of 130 μmol/L is considered mildly elevated. Some patients with elevated creatinine may be caused by their own high muscle content, or eating more meat and exercising more, if there is no abnormality in urine routine and urinary system ultrasound and other related examinations, creatinine may return to normal after adjusting the lifestyle, usually without any uncomfortable symptoms. If patients have acute kidney injury or chronic renal insufficiency due to various reasons leading to elevated creatinine, they may have discomfort symptoms such as edema, lumbago, increased nocturia, fatigue, loss of appetite and so on. If patients find that creatinine is elevated, it is recommended to go to regular hospitals in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.