Lymph nodes that are painful may not be cancer, but the presence or absence of pain in lymph nodes alone cannot determine whether it is cancer. For example, swollen lymph nodes caused by inflammation may be accompanied by lymph node pain. Lymphoma, for example, may also show swollen lymph nodes on the surface of the body, but they may not necessarily be painful and may be accompanied by systemic symptoms, such as low fever, night sweats and fatigue. Generally, if the lymph nodes do not subside or grow larger in a short period of time, cancer may be considered and further surgery is recommended to remove the lymph nodes and postoperative pathology to confirm whether it is cancer. The presence or absence of pain is not the basis for cancer diagnosis, but must be diagnosed by pathology. If it is cancer, it may be metastatic lymph node cancer that metastasized from other parts of the body, so we have to look for the primary lesion and further treatment.