What happens after I get hepatitis B? In medical terms, it is called disease regression, and in fact, the regression of hepatitis B virus infection is not always very bad. Since China is a highly endemic area for HBV infection, the HBsAg positivity rate in the general population is 9.09%. However, some people have never undergone physical examination for liver disease, so that the disease progresses to the point where liver damage has become more severe or even cirrhosis before being diagnosed with liver disease. Therefore, it is said that after having hepatitis B, a preliminary assessment should be conducted first: including 1. Inquiring about the epidemiological history and physical examination; 2. Having a family history of liver disease and hepatocellular carcinoma (HCC); 3. Laboratory tests, including routine blood, liver function, coagulation function; 4. HBV replication test: HBeAg, anti-HBe and HBVDNA; 5. Anti-HCV, anti-HDV and anti-HIV to exclude other causes of liver disease; 6. HCC screening test: alpha-fetoprotein (AFP) and ultrasonography; 7. Consider liver biopsy for grading and staging of pathological changes. Then, according to the assessment results, chronic HBV infection can be divided into: 1. Carriers Some hepatitis B virus carriers can naturally show viral regression, with an average annual regression rate of 1-2%; however, whether they can be regressed is related to certain factors. (1) The rate of HBsAg reversion in the adult group over 15 years old is higher than that in the group of children aged 1-14 years old; (2) The rate of HBsAg reversion in the low titer group is higher than that in the high titer group (>1:256); (3) The rate of HBsAg reversion in HBeAg negative people is higher than that in HBeAg positive people. (3) HBeAg-negative patients have a higher rate of HBsAg reversion than HBeAg-positive patients. They can continue to carry HBsAg for several years or even for life, with normal liver function after repeated laboratory tests and no histological damage on liver puncture biopsy. Such patients can work, study and live normally, and most of them have a good prognosis. Some patients with chronic hepatitis B can evolve into chronic hepatitis after a number of years of continuous asymptomatic carrier status, manifested by elevated transaminases, and liver histology can be seen in the necrosis, degeneration and fibrosis of liver cells. In some patients who have developed chronic hepatitis but still do not have any symptoms, and even liver function tests do not reveal any problems, then liver aspiration biopsy becomes an important basis for the diagnosis of chronic hepatitis. Therefore, liver biopsy is necessary for a definitive diagnosis. If it is confirmed that the liver has pathological damage, the appropriate and correct treatment should be carried out in time. 3.Hepatitis B cirrhosis Hepatitis B cirrhosis is the result of the development of chronic hepatitis B. The liver histology shows diffuse fibrosis and pseudobullet formation, both of which must be present at the same time to make the pathological diagnosis of cirrhosis. (1) Compensated cirrhosis: generally belongs to Child-Pugh grade A. There may be mild weakness, loss of appetite or abdominal distension, ALT and AST may be abnormal, but there is no obvious liver function loss. There may be signs of portal hypertension, such as hypersplenism and mild esophagogastric fundic varices, but no bleeding from ruptured esophagogastric varices, no ascites and hepatic encephalopathy. (2) Decompensated cirrhosis: generally belongs to Child-Pugh grade B or C. Patients often have serious complications such as ruptured esophagogastric fundic variceal bleeding, hepatic encephalopathy and ascites. Most of them have obvious loss of liver function, such as serum albumin <35g/L, bilirubin >35μmol/L, ALT and AST are elevated to different degrees, prothrombin activity (PTA) 40g/day) can lead to ALT elevation and cirrhosis, and slow hepatitis B heavy drinkers can develop cirrhosis and HCC at a very young age.