Most patients with high-grade squamous intraepithelial lesions do not have abnormal secretions, but some may have increased vaginal discharge, accompanied by foul-smelling or bloody secretions. High-grade squamous intraepithelial lesions are precancerous lesions of the cervix, which are mainly related to persistent infection with high-risk human papillomavirus. Clinically, most of the patients usually do not have obvious symptoms and abnormal secretions, but some of the patients may have increased vaginal secretions, foul-smelling secretions or bloody secretions, and contact vaginal bleeding after sex or gynecological examination. Tissue can be taken from the suspicious area under colposcopy for biopsy to determine that it can further develop into cervical cancer, which needs active treatment. Currently, the main treatment is to take surgical resection, including cervical conization and total hysterectomy, etc., of which total hysterectomy is mostly used for those who do not have reproductive requirements and are older. If high-grade squamous intraepithelial lesions are found, it is recommended to treat them as early as possible under the guidance of a physician.