Prior to paclitaxel chemotherapy, oral hormonal drugs are usually administered in advance to act on the immune system, which can better avoid the occurrence of allergic reactions. A shot of hormone, such as dexamethasone, can be administered intramuscularly 30 minutes before the infusion, or a receptor H2 receptor antagonist, such as benadryl or ranitidine, can better avoid the occurrence of adverse reactions. Once an adverse reaction has occurred, if the patient has a mild adverse reaction, the titration rate can be slowed down. If the situation is more serious, the patient should be resuscitated and the drug should be stopped in time. The most important adverse reaction in the clinical use of antineoplastic drugs is allergic reaction, which occurs very quickly, usually in 5-10 minutes, some patients can have obvious reactions, the most intuitive expression is shortness of breath and skin rash. Clinical use should be very careful, because the mechanism of allergy is mainly due to the fact that paclitaxel itself is difficult to dissolve in water. The solvent itself can cause allergic reactions, mainly type I allergic reactions, which can cause histamine release, and some patients can show very obvious performance, such as shortness of breath, which can be fatal in serious cases.