The onset of the disease is usually between 3 and 12 years old, more in boys than in girls. The main manifestation is multi-site, involuntary, sudden muscle twitching, usually the head and facial muscles are involved first, manifested as nodding, blinking, pouting, snorting, shrugging; gradually develop to the extremities and trunk, there may be a side of the throwing movement, spinning, kicking legs, etc.. 1.Twitching episodes are frequent, a dozen to hundreds of times a day. 2. Some patients have abnormal guttural sounds such as barking, growling, guttural sounds, hey, ah-ha, etc., as well as stereotypical cursing and obscene phrases. 3. Behavioral changes, manifested as restlessness, hypersensitivity, irritability or behavioral withdrawal. In severe cases, compulsive behavior, attention deficit, hyperactivity, disruptive behavior, poor learning, etc. 4. Involuntary movements and abnormal pronunciation disappear during sleep, and are relieved when the mind is relaxed, and aggravated when the mind is tense and crowded. 5. The duration of the disease is generally long, and intelligence is generally unaffected. 6.Neurological examination generally has no positive signs, and a few have bilateral fine motor asymmetry, etc.