It is best not to take lansoprazole at night. Lansoprazole is a proton pump inhibitor, the main effect is to block the activity of the proton pump in the stomach wall and inhibit gastric acid secretion so as to achieve the effect of reducing gastric acid secretion. When taking lansoprazole, you should try to take it in the morning, as the drug can be better absorbed in the morning, so that the components of the drug can give full effect. But in the evening, most people have already eaten dinner, and if you take lansoprazole at this time, the active ingredients of the drug will not be completely absorbed by the body. It may even be excreted together with food, thus causing the therapeutic effect to be affected. Some people taking lansoprazole at night may also cause adverse reactions, such as headache, dry mouth, itchy skin, etc. It is better to take lansoprazole with gastric mucosal protective agents, such as colloidal bismuth and aluminum thioglycollate, for better treatment of stomach diseases.