Trigeminal neuralgia may cause root pain, but patients should first visit a dentist for evaluation to rule out dental disease. Trigeminal nerve mainly innervates sensation in the head, face, nasal cavity and mouth, and is divided into ophthalmic nerve, maxillary nerve and mandibular nerve, of which the maxillary and mandibular nerves send out branches to innervate the mucous membranes of the oral cavity, including the tongue, roots of the teeth, upper and lower alveoli, etc. Therefore, trigeminal neuralgia may lead to tooth root pain. Besides trigeminal neuralgia, root pain may also be caused by the tooth itself, such as wisdom tooth pericoronitis, apical inflammation, periodontitis, etc. Patients are advised to go to the dentist for evaluation and exclusion of oral diseases. Patients who experience discomfort such as root pain should seek medical attention in a timely manner to clarify the specific cause of the condition under the guidance of a physician before targeting treatment.