Scleroderma of the extremities is generally defined as a connective tissue disorder in which scleroderma appears on the extremities and may be caused by factors such as heredity, immune-vascular damage, and abnormalities in collagen synthesis that harden the skin and internal organs. Scleroderma may be related to immune abnormalities, vascular endothelial cell activation, fibroblast over-activation, etc. Patients may have edematous erythema, hyperpigmentation, hypopigmentation, etc. Clinical manifestations such as Raynaud’s phenomenon, arthralgias, etc., may occur in cases of multi-system involvement. There is no specific drug for the treatment of this disease, and glucocorticosteroids such as prednisone, immunosuppressants such as cyclosporine, azathioprine, cyclophosphamide, calcium channel blockers such as nifedipine can be used to relieve the symptoms and control the condition as prescribed by the doctor. Normally, you should develop good habits of work and rest, avoid trauma and infection, and do a good job of sun protection when you go out. After suffering from scleroderma, it is recommended to go to the hospital in a timely manner, under the guidance of the physician to carry out the relevant treatment, to avoid delaying the condition.