Alcohol has definite damage to certain organs of the body, such as to the liver. So when you have a cold, if it causes liver damage, drinking alcohol at this time can significantly aggravate the liver damage. However, the vast majority of cold symptoms are generally mild and are unlikely to cause liver damage. Therefore, drinking a little red wine after this time will not cause any discomfort in symptoms that can be felt. However, if you drink a large amount, or drink when you have a particularly severe cold that hurts your liver, it may cause serious discomfort or aggravate liver damage. In addition, some people take antibiotics such as cephalosporins in addition to cold medicine. At this time, if you drink alcohol, you are likely to have a disulfiram reaction, causing more serious discomfort, so it is not recommended to drink any alcohol during a cold.