During pregnancy preparation, women should stop smoking and drinking because alcohol and cigarettes, both of which have an effect on the body, can reduce the quality of sperm and eggs. Smoking and drinking can increase the risk of abnormal fetal development, as well as miscarriage. Therefore, during pregnancy preparation, women should quit smoking and drinking, and they should not smoke or drink during pregnancy, including men during pregnancy preparation. At the same time, during the preparation period each, it is necessary to take folic acid, which can prevent malformation of the fetal neural tube. Women who have a history of smoking and drinking are recommended to have prenatal diagnosis during pregnancy to screen for some high-risk factors and rule out abnormal fetal development. It is also important to step up maternity checkups during pregnancy to pay attention to fetal development, such as Down’s syndrome screening, 4D ultrasound, etc., all of which should be done on time.