The fastest and most effective treatment for acute attacks of gout, which cause severe joint swelling and pain, is to take anti-inflammatory and pain-relieving drugs as soon as possible. It is currently recommended that anti-inflammatory and analgesic treatment should be administered as early as possible during an acute attack of gout, usually within 24 hours, with non-steroidal anti-inflammatory analgesics being the drugs of choice, such as etoricoxib, diclofenac sodium, celecoxib, loxoprofen sodium, etc., but attention should be paid to cardiovascular and gastrointestinal adverse effects of the drugs. Colchicine is also very commonly used in the acute phase of gout, but because of its high incidence of gastrointestinal adverse reactions, and because it is easy to cause patients to stop taking it because they cannot tolerate it, colchicine is currently used for patients with contraindications to the use of nonsteroidal anti-inflammatory analgesics in the acute phase of gout. If the patient’s condition is severe and conventional drug therapy is not effective, or if there are contraindications to the use of both NSAIDs and colchicine, short-term use of glucocorticoids can be considered to control the symptoms. In addition, patients in the acute stage of gout should also drink a lot of water and urinate more to promote uric acid excretion, and prohibit drinking alcohol, eating seafood, animal offal and other foods. Therefore, drugs are still a fast and effective way to relieve joint symptoms during acute gout attacks, but they should be used under the guidance of a doctor, and patients should actively control blood uric acid levels to reduce the number of acute gout attacks and control the disease as a whole.