Endometrial mesenchymal sarcoma is endometrial mesenchymal sarcoma, which is a tumor originating from endometrial mesenchymal cells, usually malignant, but with a different prognosis. Endometrial mesenchymal sarcoma includes low-grade malignant and highly malignant endometrial mesenchymal sarcoma, low-grade malignant lesions account for about 80% of the cases, with slow progression of the disease and better prognosis. Highly malignant lesions are highly malignant, with rapid disease progression, easy invasion and metastasis, and poor prognosis. Patients usually have irregular vaginal bleeding, increased menstruation, increased uterine volume and excessive vaginal discharge, etc. For patients who have been diagnosed with endometrial mesenchymal sarcoma, it is recommended that they go to the gynecology department of regular hospitals for consultation, and actively treat the disease under the guidance of the doctor through surgery, chemotherapy, radiotherapy, etc. with a view to obtaining the best therapeutic effect and prolonging the duration of life.