According to the different stages of syphilis in pregnant women, the corresponding appropriate penicillin regimen is used for treatment, with the same usage and dosage as in other syphilis patients during the same period (but tetracycline and doxycycline are prohibited), and the course of treatment can be increased if necessary. Procaine penicillin G, 800,000 units/d, intramuscularly for 10 d. One course of injection during the first 3 months of pregnancy and one course of injection at the end of 3 months of pregnancy. For those who are allergic to penicillin, only erythromycin is used for treatment, 500 nag per dose, 4 times/d, for 15 d for early syphilis and 30 d for stage II recurrent and late syphilis. one course of treatment is given in the first 3 months of pregnancy and one course in the last 3 months of pregnancy. However, the infants born to them should be treated with penicillin supplementation. Feng Zhihong, Department of Dermatology, Workshop