If there are hard nodules of tissue at the vulva, it must be paid great attention in clinical practice. Because this condition is commonly caused by the following reasons: 1. Hard nodules caused by syphilis spirochete infection, so painless nodules will be felt at the vulva. There are no symptoms in the clinic, only that the patient unintentionally found a hard nodule in the vulva. It is recommended that blood tests can be taken to find out whether there is syphilis infection. 2. It is caused by vulvar cancer, in which case ultrasound examination should be done if necessary to understand the nature of the hard tissue. Preliminary diagnosis can be made through ultrasound examination, and pathological examination is also needed clinically if necessary. The local mass tissue will be biopsied and sent for pathological examination, and the clinical diagnosis will be based on pathology.