The causes of roughness of the mucous membrane of the back wall of the stomach include gastritis, gastric ulcer and gastric cancer, etc. You can improve the symptoms through medication and surgery under the guidance of your doctor after clarifying the causes of the disease. 1. Drug treatment: gastritis and gastric ulcer can take drugs to protect gastric mucosa, such as misoprostol and aluminum thioglycollate, etc.; take proton pump inhibitors such as omeprazole to inhibit the secretion of gastric acid; take drugs to promote gastrointestinal peristalsis, such as domperidone, etc.; when there is Helicobacter pylori infection, quadruple therapy can be used, such as omeprazole, bismuth potassium citrate, amoxicillin and clarithromycin. Gastric cancer patients can take chemotherapeutic drugs such as vincristine, cisplatin and targeted drugs such as trastuzumab to slow down the progress of cancer. Due to the individual differences and the diversity of causes, there is no absolute most effective drug, so it is necessary to follow the doctor’s instruction, consult the doctor in time if there is any adverse reaction, and forbidden for those who are allergic to drugs. 2. Surgery: Early gastric cancer can be treated by surgery to remove the lesions, and the specific surgical plan needs to be evaluated by professional doctors. The specific surgical plan needs to be evaluated by professional doctors. After actively cooperating with doctors to receive treatment, the prognosis of the disease can be significantly improved.