Patients with cytomegalovirus pneumonia commonly have glassy, corn-like or nodular changes in both lungs on chest radiographs and CT. Cytomegalovirus (CMV) is a viral pneumonia characterized by the formation of large type A eosinophilic intranuclear and intracytoplasmic inclusions in infected cells. Most are asymptomatic occult infections, but in immunocompromised and infants can cause severe lung infections leading to death. In recent years with the introduction of bone marrow and organ transplants and the increasing number of AIDS patients, CMV has become the most common causative agent in both conditions. Cytomegalovirus belongs to group B herpes viruses, which are double-stranded DNA viruses with an outer envelope and a spherical nucleus. CMV has two types of antigens, complement binding antigens and neutralizing antigens. The former exists mostly in the form of soluble antigens, while the latter is mainly composed of glycoproteins and is one of the components of the viral envelope.CMV infection is strictly species-specific, and humans are only infected by human cytomegalovirus, which grows and multiplies slowly in cells (2-3 months to show obvious lesions). Infected cells have enlarged nuclei and increased cytoplasm, forming typical eosinophilic intranuclear and intracytoplasmic inclusion bodies. The following diseases are also causes of hairy glassy corn-like or nodular changes in both lungs: 1. Pulmonary geotrichosis Pulmonary geotrichosis is a bronchopulmonary lesion caused by Candida geotrichum (geotrichum candidum). Clinical manifestations are similar to bronchitis and tuberculosis, manifested by cough, coughing, mucus-like or gelatinous sputum, sometimes with blood in the sputum, fever, fatigue, chest tightness, dyspnea, etc. In some cases, wet rales can be heard at the base of the two lower lungs on auscultation. 2, cytomegalovirus pneumonia Cytomegalovirus (CMV) is a viral pneumonia characterized by the formation of large type A eosinophilic intranuclear and intracytoplasmic inclusion bodies in infected cells. Most are asymptomatic occult infections, but in immunocompromised and infants can cause severe lung infections leading to death. In recent years with the introduction of bone marrow and organ transplantation and the increasing number of AIDS patients, CMV has become the most common causative agent in both conditions.