Long blisters between the toes may be tinea pedis, friction blisters, sweat blisters, etc., can be treated with medication and enhanced care. 1. Tinea pedis: this is caused by dermatophytes, fungal infections of the skin of the foot, the more common is red trichophyton and tinea pedis, can be applied locally miconazole, econazole, ketoconazole, naftifine cream and other creams, if the lesion area is relatively large, you can take oral terbinafine, itraconazole and other drugs at the same time. 2. Friction blisters: long time wearing unsuitable shoes, or long time walking will cause friction on the toe area, blisters, for some smaller blisters, generally no obvious symptoms, do not need special treatment, pay attention to personal hygiene, you should choose loose and comfortable shoes, cotton socks, and reduce the long time walking, so that can be relieved. 3. Sweat herpes: this is a symmetrical skin disease that occurs in the hands or feet area, this disease will subside on its own in a few weeks, if there are no symptoms, you can not treat for the time being, pay attention to keep the skin fresh and clean to reduce the stimulation, do not be in a hot and humid environment for a long time. Blisters between the toes do not hurt or itch should always observe the situation, if the condition lasts a long time aggravated, to seek medical attention in a timely manner. If you need to use medication, you should strictly follow the doctor’s instructions.