Mother-to-child transmission is one of the main ways of hepatitis B infection. It is understood that up to 50% of chronic hepatitis B virus infections in China are caused by mother-to-child transmission, and the younger the age at the time of infection, the higher the probability of becoming a chronic carrier, so interrupting mother-to-child transmission of hepatitis B is the focus of prevention and treatment. Having a father who is a carrier of hepatitis B virus also has an impact on the next generation. The first is the transmission of hepatitis B virus, but the chances are much less than mother-to-child transmission; the second is the possibility of passing on the susceptibility gene of hepatitis B virus to the next generation, making their children vulnerable to hepatitis B virus. Although the chances of father-to-child transmission are smaller, attention should be paid to prevention. Especially if the male partner is a carrier of hepatitis B virus and the female partner is not infected, the female partner must be vaccinated against hepatitis B in time to prevent the transmission of hepatitis B virus from the male partner to the female partner and then from the female partner to the mother.