Avanafil and sildenafil are both type 5 phosphodiesterase inhibitors, clinically used in the treatment of erectile dysfunction, so there is no better, according to the patient’s specific condition to choose the right drug for treatment. 1. Avanafil: clinically, it is mainly used for the treatment of male erectile dysfunction, but in the process of use, some patients can appear headache, nasopharyngitis, flushing, nasal congestion, lumbar pain, muscle pain and upper respiratory tract infections, bronchitis, influenza, sinusitis and other adverse reactions; in addition to allergies to the drug, patients taking nitrate, women are prohibited from taking. 2. Sildenafil: type 5 phosphodiesterase inhibitors, clinically also used in the treatment of erectile dysfunction of commonly used drugs, in the process of taking, some patients can appear facial edema, photosensitivity, shock, migraine, vomiting, feeding, asthma, urticaria, tinnitus and eye pain and other discomfort. In addition, sildenafil can enhance the antihypertensive effect of nitrate, so patients taking nitrate are prohibited from taking the drug; patients allergic to the drug, myocardial infarction, shock or arrhythmia within the best six months of the existence of patients, but also to take with caution. So for patients who want to take avanafil or sildenafil to treat erectile dysfunction, you can choose the right drug for treatment under the guidance of your doctor.