Survival period after surgery for middle and late stage colorectal cancer cannot be generalized, and it is related to the severity of the patient’s disease, personal physical condition, treatment means, etc., and the specific time varies from person to person. After active comprehensive anti-tumor treatment, there is hope for more than 3-5 years of survival. Tumor cells of patients with mid-late stage colorectal cancer usually have invaded parietal and mesenteric lymph nodes, mesenteric root lymph nodes, and multiple metastases have occurred. Even if radical surgery is used, the infiltrating tumor foci and distant metastatic tumor foci cannot be completely resected, so the cure cannot be achieved. Therefore, clinically, for the middle and late stage of colorectal cancer, adjuvant chemotherapy and targeted drugs are mostly adopted for translational treatment, so that the non-surgically resectable tumors can be shrunk or staged down to resectable bowel cancer before radical surgery is performed, and the 5-year survival rate of the patients will also be improved. Even if stage I surgery cannot be done, the progression of the disease can be controlled and the survival period can be prolonged. It is also suggested that patients should actively adjust their lifestyles, maintain an optimistic mindset, and actively cope with the disease by cooperating with doctors to participate in the treatment. Diet should be light and nutritious, avoid smoking and alcohol, should strictly follow the doctor’s instructions for medication, regular review.