The white spots on the skin can be considered as vitiligo, senile white spots or anemic nevi and many other skin diseases. 1. Vitiligo: the onset of the disease can be related to heredity, psycho-neurological factors or immunity and other factors, belongs to the skin and mucous membrane pigmentation disorder, all parts of the body can appear, the color of the lesion area is reduced, whitening, can be enlarged and fused into a large sheet, the generalization of the whole body. 2. Geriatric leukoplakia: it belongs to senile degeneration phenomenon, often accompanied by other geriatric changes such as gray hair, senile warts, etc. There are a number of white spots ranging from a pinhead to a bean-sized white spot on the thighs, limbs, trunk, etc., and the skin at the white spot can be slightly sunken. 3. Anemic nevus: this disease is rare, belongs to the congenital function abnormality, is a kind of vascular tissue development defects, anemic nevus occurs in the trunk, face, limbs can also be involved, can be seen in round or irregular shape of the size of the pallid spot. There are many other causes of leukoplakia, so it is recommended that patients go to a regular doctor in time to get a clear diagnosis and follow the doctor’s instructions, so as not to delay the condition and cause adverse consequences.