Liver cancer needs to take targeted drugs for a long time after surgery. After surgical treatment, patients with intermediate and advanced liver cancer should also take targeted drugs as prescribed by doctors in order to effectively inhibit the spread of cancer cells, try to slow down the process of deterioration of the disease and prolong the survival period of patients. When the targeted drug is resistant to the drug, the patient should stop taking the targeted drug or change to other targeted drugs for treatment. If liver cancer patients do not have the condition of surgical treatment and need to take targeted drugs for treatment, as long as there is no side effect, the longer the time of taking targeted drugs is the better. However, once patients have adverse reactions when taking targeted drugs, they should stop taking them in time and go to oncology department of hospital as soon as possible. The duration of taking targeted drugs after liver cancer surgery is not specified, but mainly depends on the patient’s tolerance of targeted drugs. In terms of the usage and dosage of the targeted drugs, it is necessary to follow the doctor’s advice and not to adjust the dosage on one’s own.