Azithromycin and cephalosporin both belong to the antibacterial drugs, generally do not combine drugs, easy to cause antibiotic abuse. If the use of azithromycin effect is not good need to change the drug, it is generally recommended to eat azithromycin one day after the cephalosporins, azithromycin will be metabolized to a safer range of blood concentrations, and then eat cephalosporins safer. Azithromycin belongs to the macrolide class of drugs, on the gram-positive cocci, gram-negative cocci, whooping cough bacilli, Legionella pneumophila, Mycoplasma pneumoniae, Chlamydia, anaerobic digestive cocci, etc. have antibacterial efficacy. Gastrointestinal reactions are common after use of the drug, and may also cause hepatomegaly, deafness, tinnitus and other adverse reactions. Allergy to macrolides, hepatic insufficiency, jaundice patients are prohibited. Cephalosporins exert antibacterial efficacy by inhibiting the synthesis of bacterial cell walls, and these drugs are divided into four generations, with the antibacterial spectrum gradually expanding and nephrotoxicity gradually decreasing. This kind of drug is easy to cause allergic reactions, before using the drug need to do skin test, positive reaction patients are prohibited. Do not drink alcohol after using the drug, it will cause disulfiram-like reaction. Note that this kind of drug is prohibited for those who are allergic to this kind of drug. Patients should use the drug under the guidance of a professional physician, do not stop or change the drug without authorization.