Luminal cerebral infarction usually requires long-term administration of antiplatelet drugs and plaque stabilizing drugs. Antiplatelet drugs usually include aspirin, clopidogrel, tegretol, etc., and plaque-stabilizing drugs include atorvastatin, resuvastatin, etc. Antiplatelet aggregating drugs and plaque-stabilizing drugs are the main drugs for secondary prevention of cerebral infarction. Once suffered from lacunar cerebral infarction, the above drugs should be taken for a long time to prevent stroke recurrence. In addition, patients with lacunar cerebral infarction need to control other risk factors, such as hypertension, hyperlipidemia, hyperglycemia, etc., and should quit smoking and drinking, eat a low-salt and low-fat diet, exercise appropriately, and have a stable state of mind to maximize the prevention of stroke recurrence.