Chronic inflammation of transverse colon mucosa with lymphatic tissue hyperplasia can be treated with dietary modification, medication and surgery. 1. Dietary modification: when the patient only occurs transverse colon mucosa inflammation, lymphatic tissue mild hyperplasia, can not use drug treatment, can adjust the diet, less spicy and stimulating food, so as to reduce the stimulation of the colonic mucosa. 2. Drug treatment: Inflammation of transverse colon can be controlled, you can use aminosalicylic acid preparation, salazosulfapyridine and other drugs under the guidance of the doctor, and in serious cases, you can use prednisone, methylprednisolone and other drugs. 3. Surgery: For patients with more serious lymphoid hyperplasia, we can consider doing pathological examination of the lesion area, and surgical resection can be carried out if necessary. For patients with lymphoid hyperplasia of transverse colon mucositis, it is better to do regular review and follow the doctor’s advice for treatment.