Weak positive Helicobacter pylori indicates infection with Helicobacter pylori. Those with peptic ulcer, early postoperative gastric cancer, gastric lymphoma, active gastritis, and gastroesophageal reflux need to take quadruple drug therapy in time, i.e., two antibiotics + a proton pump inhibitor + a bismuth agent, e.g., Clarithromycin, Amoxicillin, Omeprazole, and Bismuth Potassium Citrate. 1. Clarithromycin belongs to macrolide antibiotics, which is suitable for eradicating Helicobacter pylori, thus reducing the recurrence of duodenal ulcer. However, it should be used with caution in people with abnormal liver function, and those who are allergic to macrolides need to disable this drug. 2. Amoxicillin is a broad-spectrum semi-synthetic penicillin with a strong bactericidal effect. It is suitable for the treatment of infections caused by sensitive bacteria (gastrointestinal tract infections, urinary tract infections and respiratory tract infections, etc.). However, the drug is also associated with adverse reactions, i.e. allergic reactions, anxiety, nausea and vomiting. 3. Omeprazole can specifically inhibit the hydrogen ion pump enzyme system of gastric wall cells blocking the secretion of gastric acid. It is commonly used in gastric ulcer, duodenal ulcer disease and other conditions. Adverse reactions include headache, abdominal pain, constipation and other conditions. 4. Bismuth can form a diffuse protective layer covering the ulcer surface in the acidic environment of the stomach, preventing the attack of gastric acid. It is mainly used for chronic gastritis, gastroesophageal reflux and other diseases. Adverse effects include gray-black stools and tongue coating, ammonia taste in the mouth and other conditions. All of the above medications should be taken under the guidance of a medical professional. If Helicobacter pylori is weakly positive, please consult a doctor for reasonable and standardized treatment.