September 28th was a heavy day. The company’s main business is to promote the development of the company’s products and services. The company’s newest product is a new product that will be available in the marketplace.
The reason for their departure is similar, as they both died of a major disease unique to China – hepatocellular carcinoma;
Both also left because of a hobby unique to many Chinese men – drinking.
Zang Tianshuo, whose most famous masterpiece is “Friends,” said, “If you have a new shore, please leave me,” raising genuine friendship to a new level of selflessness. The man as the song is named, he was particularly righteous and righteous, and he loved to drink very much during his lifetime. But little did he know that this hobby would inadvertently sow the seeds of trouble.
One of Shi Shengjie’s classic works is “Drunken Songs,” and the fact that he suffered liver metastases from pancreatic cancer in his later years may also have had a lot to do with his love of alcohol as a young man. The company’s main business is to provide a wide range of products and services to the public. The company’s main goal is to provide the best possible service to its customers. They are the most popular and most popular of all.
-01 Why is the love of alcohol closely related to liver cancer?
We all know that “drinking hurts the liver” because 90% to 98% of alcohol is metabolized by the liver. Studies have found that there is a relationship between alcohol and the development of liver cancer, especially with long-term alcohol consumption.
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What is the concept of long-term drinking? Is it drinking alcohol every day for decades?
No, it’s not. As long as you’ve been drinking for more than 5 years, and your equivalent alcohol consumption is no less than 40 g/d for men and 20 g/d for women, you’re a long-term drinker.
What is 40 g of alcohol per day? For men, this is the equivalent of two bottles of beer (1000 ml), two glasses of red wine (500 ml), or two taels of white wine (100 ml).
Epidemiological studies have found that the risk of liver cancer is 7.4 and 6.5 times higher in mixed or hard liquor drinkers than in non-drinkers, respectively, and that the risk of liver cancer is 3.1 times higher in habitual drinkers (who drink no less than 3 days a week for more than 5 years) than in non-habitual drinkers.
Is the transition from habitual drinking to liver cancer unpredictable?
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This is not the case. People who drink excessively over a long period of time typically develop alcoholic fatty liver, alcoholic hepatitis, then alcoholic cirrhosis, and then liver cancer as the final step. Studies have found that 29.6% of long-term drinkers develop cirrhosis and about 9.2% develop liver cancer.
And in patients with cirrhosis, the role of alcohol cannot be underestimated. In patients who drink, 25.3% develop liver cancer, while only 13.5% of those who don’t drink develop liver cancer.
In addition, patients with chronic hepatitis B and C are at high risk for liver cancer, and when combined with long-term alcohol use, the “triple step” of liver disease is accelerated.
-02 Drinking in moderation is not good for you, and neither is red wine
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Everyone who loves to drink is surrounded by a group of family members who are trying to advise them, but in the end, it never ends.
They may even say to you, “A little wine every day in moderation is good for your health, I’m taking care of it.”
Is there really a benefit to drinking alcohol in moderation? It’s time to offer up this research.
In early 2018, a team of researchers from the University of Cambridge published a study in the top journal Nature that found that acetaldehyde, a metabolite of alcohol, directly disrupts DNA structure, induces genetic mutations, and even causes severe chromosomal rearrangements. Such mutations accumulate not only to elevated cancer risk, but also to massive mutations in blood-forming stem cells, triggering a decline in immune cell function and even leading directly to blood disorders such as leukemia.
And, this DNA damage is permanent and irreversible.
Sadly, it just so happens that acetaldehyde dehydrogenase (ALDH2) deficiency is very common in East Asian countries such as China, Japan, and Korea, with roughly 2 out of 5 people. People who are deficient in this enzyme have difficulty metabolizing the acetaldehyde that accumulates in the liver quickly, leading to a higher risk of DNA mutations.
Even people who are not deficient in this enzyme are not infallible, because the body’s ability to metabolize alcohol and repair DNA is not as flawless.
The latest analysis from the Global Burden of Disease Study (GBD), published online by The Lancet on August 23, 2018, shows that 0 standard drinks/day has the lowest relative risk for overall health outcomes, and that the relative risk is increasing as daily drinking increases.
That is, not drinking at all is the healthiest. Although moderate alcohol consumption may be protective against ischemic heart disease, it also increases the risk of cancer, and this protective effect is offset.
So, it is still recommended that people drink as little as possible. People who don’t drink in the first place don’t need to drink for the so-called “cardiovascular benefits”.
-03 Is it hard to detect liver cancer early?
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No, it’s not. The abdominal ultrasound, CT scan, and fetoprotein tests that are part of the usual physical exam are all effective ways to screen for liver cancer.
Among these, AFP, which requires a blood test, is the most personal tumor marker for liver cancer. However, other cancers and special conditions (including pregnancy, hepatitis, etc.) may also cause an increase in AFP, which requires flexibility in conjunction with other test results.
In addition, it is important to pay attention when there are changes and discomfort in the body.
The early symptoms of liver cancer are less obvious, and the late stage may show upper abdominal pain, nausea and vomiting, weakness, lethargy, yellowing of the skin and urine (jaundice), etc., which in turn are easily ignored or mistaken for other diseases. It is not known that these are most likely signs of the occurrence of liver cancer, and delaying to go to the hospital often delays the best time for treatment.
And the way to prevent liver cancer is really simple – in addition to getting the hepatitis B vaccine, not eating moldy foods, and most importantly, staying away from tobacco and alcohol.
In short, Chinese culture has given alcohol too much of a spiritual dimension to aspire to, with “drinking to quench sorrow,” “drinking to strengthen the nerves,” “wine to help poetry,” and ”
In short, Chinese culture has given alcohol a lot of spiritual aspirations.
There are reports that during his treatment for his illness, the “wine immortal” of many years finally gave up drinking, but unfortunately it was too late.
I think what the master wants to tell everyone is the same thing: Drink less, watch out for your liver.