When the Down screening alpha-fetoprotein is a little bit low, it is not possible to accurately determine whether it is important or not, and you need to follow the doctor’s instructions to carry out other tests, such as non-invasive DNA test, etc. If there is no abnormality, then it does not matter, and if the results have abnormalities, then it is necessary to carry out diagnosis and treatment under the guidance of the doctor. An alpha-fetoprotein measurement is usually performed during pregnancy tests to determine whether the fetus is at risk for Down syndrome. The lower the alpha-fetoprotein, the higher the risk of Down’s syndrome in the fetus. Therefore, when the alpha-fetoprotein is low, the pregnant woman should be vigilant and need to be re-tested. If the results are normal, regular checkups will be sufficient. If the results are abnormal, non-invasive DNA testing will be required. If the fetus is diagnosed with Down syndrome, the pregnancy should be terminated promptly. If the growth and development of the fetus is normal, it is necessary to pay attention to the health of the pregnancy and take obstetric examinations on time. If the Down’s syndrome screening test result is low, the pregnant woman should seek medical advice from her doctor for further intervention.