Pressure and postural hyperhidrosis is the sweating response to pressure on one side of the body during position changes and lateral recumbency. It is a manifestation of hyperhidrosis. Hyperhidrosis is a disorder in which excessive sweat gland secretion is caused by sympathetic hyperexcitation. The sympathetic nerve governs sweating throughout the body. Under normal circumstances, the sympathetic nerve regulates body temperature by controlling sweating and heat dissipation. In hyperhidrosis, however, sweating and facial flushing are completely out of control. Excessive sweating and facial flushing leave the patient in a daily state of helplessness, agitation or panic. How can stress and postural hyperhidrosis be effectively prevented? There are no better measures to prevent sweating, whether it is caused by systemic diseases, psychogenic sweating or gustatory sweating, but the main thing is to prevent related diseases. If there is a background of hereditary syndrome, preventive measures include the introduction of genetic counseling, carrier genetic testing and prenatal diagnosis and selective abortion to prevent the birth of affected children. Relaxation, attention to personal hygiene, frequent bathing and changing of clothes. Systemic hyperhidrosis is difficult to control and the focus is on treating the underlying disease associated with it. Palmoplantar hyperhidrosis is mainly treated locally. Axillary hyperhidrosis is often treated less effectively than palmoplantar hyperhidrosis. 1. Drug treatment (1) Topical drugs. Commonly used antiperspirants include 20% to 25% aluminum chloride solution, 0.5% aluminum acetate solution, 3% to 5% formaldehyde solution, 5% alum solution, and 5% tannic acid solution. Topical medications used too many times can cause local dryness, mild chafing or severe irritation. (2) Internal medication. Systemic hyperhidrosis is mainly the treatment of related primary diseases. Sedatives (phenobarbital, isopentobarbital, scobarbital, clomazepam, etc.) and small doses of anxiolytics (diazepam, hydroxyzine, doxepin, etc.) are effective for emotional hyperhidrosis. Larger doses of anticholinergics only have the effect of inhibiting sweat secretion and can cause unbearable dry mouth, so they tend to be eliminated. (3) Physical therapy. Tap water iontophoresis therapy for patients who have failed local (palmoplantar, axillary) topical treatment. Contraindicated in those with pacemakers. Superficial X-ray irradiation inhibits sweat gland secretion and is indicated only for patients with severe palmar-plantar hyperhidrosis who have failed other treatments. (4) Local injection of botulinum toxin A (BTX-A). Mostly used for the treatment of palmoplantar and axillary hyperhidrosis. Generally 5-7 days after the injection, the antiperspiration is obvious and can be maintained for 9-12 months on average. 2.Surgical treatment Selective excision of the second to fourth pair of thoracic sympathetic nerves has significant effects on palmar, axillary, thoracic and facial hyperhidrosis, but it is not suitable for patients with plantar hyperhidrosis. The procedure can lead to permanent anhidrosis and compensatory hyperhidrosis in other areas, so it should be used with caution. For axillary hyperhidrosis only, the most actively secreting part of the sweat gland in the axilla can be selectively removed, and this method has positive results.