Demyelinating disease is a group of diseases in which the myelin sheath is lost or thinned while the axon is relatively intact. The pathological change is the loss of myelin from nerve fibers while the nerve cells remain relatively intact, impairing the transmission of nerve impulses. The following diseases can cause demyelination, as described below. 1, systemic vasculitis caused by nerve damage: vasculitis (vasculitis), also known as inflammatory vascular disease, refers to the inflammatory disease of the blood vessels, which can be infectious or non-infectious disease. 2, monoclonal gammopathy with peripheral neuropathy: monoclonal gammopathy combined with peripheral neuropathy, also known as paraproteinemia peripheral neuropathy. 3, somatic diseases with mental disorders: mental disorders due to somatic infections are extracerebral systemic infections caused by viruses, bacteria, spirochetes, fungi, insects or other microorganisms, parasites, etc., such as sepsis, syphilis, typhoid, typhus. 4, spinal vascular malformation: less common, the most common manifestation is subarachnoid hemorrhage or spinal cord hemorrhage. Spinal vascular malformations can occur in any segment of the spinal cord, but most commonly in the cervical segment and conus.