Closed mouth pimples are classified as acne. A face full of closed mouth pimples can be treated by medication, physical therapy and general treatment. 1. Medication: Vitamin A acid drugs such as vitamin A cream, adapalene gel, tazarotene ointment can be applied externally to the affected area, and benzoyl peroxide gel or azelaic acid can also be used to dissolve keratin to treat. If necessary, oral isotretinoin soft capsule can be taken. 2. Physical therapy: patients can go to the hospital, by a professional doctor using a sterile acne needle to squeeze out the acne contents, and then disinfected. Or use photorejuvenation and other laser methods of treatment also have a certain effect. 3. General treatment: In life, patients should pay attention to daily cleaning, avoid oil adhering to the face to block pores, avoid squeezing or scratching acne, also avoid using cosmetics, avoid staying up late; diet, avoid spicy and stimulating food. If you have a face full of symptoms of closed mouth acne, it is recommended to consult a doctor as soon as possible, and follow the doctor’s instructions for treatment. Medications need to be used under the guidance of a doctor.