Purpura nephritis is the result of allergic purpura leading to kidney damage. The pathogenesis of this disease is mainly due to abnormal humoral immunity, but also cellular immune dysfunction, the involvement of cytokines and inflammatory mediators, etc. leading to kidney destruction, in addition, coagulation mechanisms, etc. are also involved in the occurrence of purpura nephritis. According to the renal pathological changes as well as clinical manifestations, the following treatments can be used: 1. Adrenocorticosteroids: They have positive efficacy in relieving joint and gastrointestinal symptoms. However, a large amount of data reported that corticosteroids cannot improve and prevent renal lesions and cannot prevent the recurrence of purpura. For those who have slight change in urine routine, normal renal function, only slight change in renal biopsy or focal thylakoid hyperplasia, it is not recommended to apply hormone, but can be treated symptomatically, and strengthen the follow-up observation. 2, immunosuppressants: commonly used cyclophosphamide and other drugs. For patients with clinical manifestations of nephrotic syndrome, especially those with renal impairment and diffuse pathological changes, prednisone and other treatments or combined with cyclophosphamide are available. In nephrotic nephropathy and acute nephritis with diffuse hyperplasia and crescent formation, early hormone therapy is generally recommended. Glucocorticoids and immunosuppression (such as methylprednisolone flush or cyclophosphamide shock therapy) are commonly used. 3, anticoagulation and anti-platelet aggregation therapy: is an important treatment method. Aspirin, pentoxifylline and heparin are commonly used. 4, calcium channel blockers: can dilate blood vessels, reduce vasospasm caused by vasculitis, and inhibit platelet aggregation. At present, the clinical often use nifedipine, etc. 5, antihistamine drugs: mainly H2 receptor antagonists and so on. These drugs competitively antagonize histamine, improve vascular permeability, thereby reducing skin mucosa and visceral bleeding. It is effective in controlling rash and reducing renal injury. Commonly used for cimetidine and other drugs. 6, angiotensin converting enzyme inhibitors: such as captopril, etc. 7, other treatments: prostaglandins can improve renal microcirculation and reduce kidney damage. High-dose gammaglobulin has the effect of neutralizing the antigen in the body and inhibiting the inflammatory response. The Chinese medicine compound Salvia miltiorrhiza and Radix polygoni are also used in the treatment of this disease. Plasma exchange therapy can be performed if available to exclude immune complexes from the body and improve renal function, especially in severe or recalcitrant cases and those with severe renal impairment. Dialysis is often required for patients with severe renal failure.