A bout of headache can be oral medication to relieve pain, mainly for the use of different drugs for the disease, such as tension headache, migraine, trigeminal neuralgia and so on. 1. Nervous headache: excessive mental and nervous tension will cause the fascia or muscle contraction of the scalp, you can use ibuprofen, diclofenac and other drugs to relieve pain, and at the same time the use of anti-anxiety and antidepressant drugs to relieve tension and anxiety, such as sertraline, haloperidol melitusine tablets and so on. 2. Migraine: Migraine is a kind of throbbing headache, mainly one or both sides of the paroxysmal throbbing pain, swelling pain, you can use painkillers, acetaminophen, sumatriptan and other drugs to relieve pain. 3. Trigeminal neuralgia: This is a kind of recurrent, short paroxysmal severe pain confined to the innervation area of the trigeminal nerve, which can be relieved by the use of carbamazepine, phenytoin sodium, gabapentin and other drugs. Headaches caused by a primary disease also require active treatment of the primary disease to relieve the pain. Many kinds of diseases can lead to a burst of headache, you should seek medical treatment as soon as possible to identify the cause and then targeted treatment, do not blindly self-medication.