The main procedure of pancreaticoduodenectomy is the removal of a small portion of the stomach, all of the duodenum, a portion of the jejunum, the head of the pancreas and the leptomeninges, the gallbladder, and the extrahepatic bile ducts, as well as the completion of the functional reconstruction of the gastrointestinal tract, the bile duct, and the pancreas. Pancreaticoduodenectomy is mainly suitable for patients with tumors in the juxta-abdomen, head of pancreas, lower part of the common bile duct, and chronic pancreatitis with severe complications. First of all, it is necessary to make preoperative preparations, check whether the function of vital organs is normal or not, enhance the activity of prothrombin, make the electrolyte status balanced, and place a gastrointestinal decompression tube. The approximate steps of the procedure are: anesthesia with general anesthesia is used. A small portion of the stomach, all of the duodenum, part of the jejunum, the head of the pancreas and the leptomeninges, the gallbladder, and the extrahepatic bile ducts are removed. A support tube is placed in the pancreatic duct for drainage to minimize the probability of pancreatic fistula. Functional reconstruction of the gastrointestinal, biliary, and pancreatic bowel is accomplished after resection. Pancreaticoduodenectomy is the most complex generalized surgical procedure with many postoperative complications.