Itchy palms may be caused by localized pressure, atopic dermatitis, peripheral neuritis, cervical spondylosis, carpal tunnel syndrome and other diseases. 1. Localized pressure: prolonged compression of the palm or upper limb caused by poor local blood circulation in the palm, tissue ischemia and hypoxia and itchy palms. 2. Allergic dermatitis: after the external hair, seafood, dander, pollen, dust and other allergens come into direct contact with the skin of the palm, it induces an allergic reaction of the skin tissues, resulting in localized edema, rash, itchiness, numbness and other symptoms. 3. Peripheral neuritis: diabetes, chemical stimulation, vitamin B deficiency, autoimmune system disorders and other factors lead to peripheral nerve inflammatory lesions, involving the ulnar nerve innervating the palm of the hand, radial nerve, median nerve, etc., neurosensory and motor dysfunction, so the palm of the hand numbness and itching. 4. Cervical spondylosis: cervical vertebral hyperplasia, degeneration, deformity or cervical disc herniation leads to spinal nerve root compression near the vertebral body, and dysfunction of the distal median nerve, radial-ulnar nerve, etc., which results in numbness and itchiness in the palm of the hand. 5. Carpal tunnel syndrome: abnormal development of the carpal tunnel, external pressure on the carpal tunnel, inflammation and edema in the carpal tunnel and other factors lead to pressure on the median nerve in the carpal tunnel, so the palms of the hands itchy. Itchy palms may be related to a variety of factors, it is recommended to consult a doctor for a clear diagnosis, and follow the doctor’s instructions for treatment.