Friction sounds in the liver area are when the palm of the right hand is lightly pressed against the liver area during the examination and the patient is asked to perform abdominal breathing movements. There is no frictional sensation under the palm when normal. In perihepatitis, the surface of the liver and the adjacent peritoneum may become rough due to fibrinous exudate. The mutual friction between the two can be known by palpation and is known as hepatic friction, and as mentioned earlier, the sound heard during auscultation is the hepatic friction sound. So, what is the differential diagnosis of hepatic friction sounds? The following is a brief explanation. The differential diagnosis of hepatic friction sounds 1, hepatosplenomegaly such as hematological diseases, metabolic diseases caused by hepatosplenomegaly, liver aspiration biopsy can be done if necessary. 2, pneumoperitoneum Pneumoperitoneum has a variety of etiologies, such as tuberculous peritonitis, constrictive pericarditis, chronic glomerulonephritis, etc. According to the medical history and clinical manifestations, relevant examinations and peritoneal fluid examination, it is not difficult to differentiate from cirrhotic peritoneal fluid, and the diagnosis can often be confirmed by laparoscopy if necessary. 3. Differential diagnosis of complications of cirrhosis such as upper gastrointestinal bleeding, hepatic encephalopathy, hepatorenal syndrome, etc. Friction sounds in the liver area can occasionally be heard on the surface of the liver area, suggesting that the liver membrane is invaded by tumors. It is recommended that once patients are suspected of having symptoms of hepatic friction sounds, they should actively go to regular hospitals for systematic examination, diagnosis and treatment to achieve early detection, early diagnosis and early treatment, so as to avoid delaying the disease and causing serious consequences and regrets for life.