The best time to take vitamin B, also known as B vitamins, varies from person to person and cannot be generalized. Usually, the best time to take B vitamins is between meals, generally after lunch and before dinner, that is, around 3-5 pm, the best bioavailability of the drug, to maximize the concentration of drug absorption, to promote the absorption and digestion of drugs in the body organs, especially for the nourishment of peripheral nerves, as well as the regulation of the immune system, have a better effect and efficacy. However, if the patient has experienced upper gastrointestinal bleeding, esophagogastric fundic varices, or is suffering from active ulcers or peptic ulcers, it must be taken within 15-30 minutes after meals to reduce the stimulation of the body and damage to the gastric mucosa by B vitamins. During the dosing period, patients should pay attention to a reasonable diet, avoid drinking strong tea and coffee, and avoid eating foods with high cholesterol or greasy food. In addition, patients should avoid staying up late and quit smoking and drinking.