Common causes of increased urine creatinine: First, transient elevation of urine creatinine, after strenuous exercise due to increased metabolic rate, may increase muscle catabolism, which leads to elevated urine creatinine situation. Secondly, it is common in patients with infection, fever or acute consumption, which can lead to elevated urine creatinine due to increased sodium metabolic rate. Third, it is common in pathological factors, such as diabetes mellitus, acromegaly syndrome and hypothyroidism patients. Fourthly, it is common in patients with early renal insufficiency. These patients will have glomerular hyperfiltration and hyperperfusion in the early stage, thus leading to elevated urinary creatinine, and the endogenous creatinine clearance is also elevated at this time.